Quantification of Fat Infiltration in Thigh and Calf Muscles in Oculopharyngeal Muscular Dystrophy: Comparison of Three MRI Methods
نویسندگان
چکیده
Introduction. Oculopharyngeal muscular dystrophy (OPMD) is an autosomal-dominant muscle disorder of adult onset, which appears in individuals with a mutation on the nuclear poly(A) binding protein (PABN1) gene [1]. OPMD is characterized by bilateral, progressive muscle weakness, muscle fiber necrosis and muscle infiltration by fatty tissue. The development of non-invasive measures of the degree and progression of muscle involvement is essential for clinical trials. In this study, three quantitative measures of muscular fat infiltration are compared. The measures are evaluated with regard to applicability for longitudinal studies of the pattern and involvement of fat infiltration in OPMD patients.
منابع مشابه
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